ABSTRACT
Objective To investigate the value of CD5 molecule-like protein(CD5L) and partial pressure of CO2 in arterial blood(PaCO2) in predicting the survival of patients with severe asthma and mechanical ventilation.Methods From Jan.2013 to Jan.2016,a total of 38 patients with severe asthma and mechanical ventilation were enrolled.Acute Physiology and Chronic Health EvaluationⅡ(APACHE II)were used to assess the severity.Enzyme linked immunosorbent assay was used to detect serum levels of CD5L at admission and 6 h after treatment.PaCO2 were also detected.Pearson correlation analysis was used to analyze the correlation between APACHEⅡ score and CD5L and PaCO2 levels.Receiver operation characteristic(ROC) curve was used to evaluate the value of CD5L and PaCO2 in predicting the survival of patients.Results APACHEⅡscores of survival patients were significantly higher than dead patients(P<0.05).CD5L level of survival patients after treatment was significantly lower than dead patients,while PaCO2 level was significantly higher(P<0.05).APACHEⅡ score was negatively correlated with serum CD5L level(r=-0.347,P<0.05),while positively correlated with PaCO2 level(r=0.573,P<0.05).ROC curve analysis showed that serum CD5L and PaCO2 were with predictive value for prediction the survival of patients,with sensitivity of 93.33%,specificity of 75.00%,accuracy of 89.47%,positive predictive value of 93.33%,and negative predictive value of 75.00% for CD5L,and those for PaCO2 were 90.00%,87.50%,89.47%,97.42% and 70.00%.Conclusion With the decreasing of CD5L level and increasing of PaCO2 level,severity of disease in patients with severe asthma and mechanical ventilation could be more serious condition,indicating poor prognosis.CD5L and PaCO2 could be with fine predictive value of survival of patients with severe asthma and mechanical ventilation.
ABSTRACT
OBJECTIVE:To study the curative effect of different Chailing decoction granules on chronic renal failure(CRF) in rats.METHODS:SD rats in trial groups and model group were given adenine to induce CRF model.The trial groups were treated with Japanese Tsumura granules,imitating Japanese method granules or Chinese normal method granule.The model group and the control group were treated with saline.The urine,blood biochemical parameters as well as morphological change of kidney were monitored.RESULTS:Compared with model group,Japanese Tsumura granules and imitating Japanese method granules significantly reduced the levels of blood ureanitrogen,serum total protein,serum cholesterol and urinary protein,and the damage on renal interstitium was lessened significantly(P
ABSTRACT
By using undecalcified bone sections, accompanied by tetracycline double labeling and analysis of infrared spectrogram, the bone formation, mineralization and crystal feature of induced ectopic bone and self femora in rats were compared. The results showed that from the 21th day to the 26th day as well as from the 26th day to the 30th day of the experiment, the rate of induced bone formation, mineralization was more active than that of the self femora: on the 30th day, in the induced bone, the count of bone cell was much more, the volume of bone cell was much larger too; but the crystal structure of induced bone was indentical with that of self femora. The molecular formula was Ca_5[(OH)/(PO_4CO_3OH)_3].